Specificity of the Deletion of Chromosome #15 in Mouse Plasmacytoma: Brief Communication 2

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Abstract
Q-banding studies in two independent hyperdiploid mouse plasmacytomas, 63-1 and the NP-38-ABCD subline of MSPC-1, revealed that deletion of a #15 chromosome was common. The deletion of #15 appeared to result from a translocation between #12 and 15 in the NP-38-ABCD, as in most plasmacytomas. In 63-1, however, #10 was probably a recipient chromosome of the missing segment from the deleted #15, and both chromosomes #12 remained intact. These karyotypic features suggest that the deleted #15 is a tumor-specific marker chromosome in mouse plasmacytoma and that an abnormality of #12 is not essential for development of the tumor. The constitution of chromosomes in the two plasmacytomas remained remarkably stable in their homogeneous modal population.

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