Replication and inactivation of and isodicentric X: presence of an inactive centromere influences the replication patterns
- 28 June 2008
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 24 (3) , 180-183
- https://doi.org/10.1111/j.1399-0004.1983.tb02236.x
Abstract
An isodicentric X-chromosome (idic(X)(pter .fwdarw. q23::q23 .fwdarw. pter)) was found in a phenotypically normal 30-yr-old female with symptoms of premature menopause. A study of DNA replication revealed that in a proportion of cells there was an asymmetric pattern of replication. The region with the inactive centromere had a tendency to replicate later than the portion with the functioning centromere.Keywords
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