Polyclonal expansion of T cells with the TCR Vbeta type of the tumour cell in lesions of cutaneous T-cell lymphoma: evidence for possible superantigen involvement

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Abstract
The involvement of superantigens in the pathology of cutaneous T‐cell lymphomas (CTCL) has been suggested before, but without unequivocal evidence for superantigen activity in the patients. Seeking evidence for superantigen activity we analysed clones and microdissected single cells isolated from the epidermis of early‐stage lesions of a CTCL patient for their T‐cell receptor (TCR) Vβ expression and TCR Vγ gene rearrangements. The vast majority of these T cells expressed the TCR Vβ family type of the tumour. From their TCR γ gene rearrangements, however, these cells were polyclonal. The tumour cell clone accounted for about 60% of these cells, about 40% were of heterogeneous origin. This dominance of a single Vβ family in the polyclonally expanded dermal T‐cell populations implies superantigen activity in the CTCL lesions.

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