Atypical antidopaminergic properties of CI-686: A potential antipsychotic agent
- 1 November 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 66 (1) , 23-27
- https://doi.org/10.1007/bf00431984
Abstract
The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.This publication has 21 references indexed in Scilit:
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