PHARMACOLOGICAL ANALYSIS OF THE EFFECTS OF METOCLOPRAMIDE ON THE TRANSMURALLY STIMULATED GUINEA-PIG ILEUM

  • 1 January 1979
    • journal article
    • research article
    • Vol. 242  (1) , 149-158
Abstract
The effects of metoclopramide (Mcp), a benzamide derivative, were quantitatively analyzed on the responses of the isolated guinea-pig ileum to transmural stimulation. Mcp (0.03 .mu.g/ml upwards) increased these responses but this effect which was Ca-dependent was not concentration-dependent (up to 30 .mu.g/ml). Mcp antagonized the inhibitory effects of noradrenaline [norepinephrine], dopamine, procaine, ATP, bufexamac and hydrocortisone on the ileal responses, but not those of tetrodotoxin and verapamil.

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