SUBACUTE BACTERIAL ENDOCARDITIS

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Abstract
The treatment of subacute bacterial endocarditis has been divided historically by most authors into three distinct periods of time. The first encompasses the period before the use of sulfonamide drugs, when it was estimated that the incidence of spontaneous recovery varied between 0 and 1 per cent. The second phase began with the use of sulfonamide drugs, either with or without fever therapy. Lichtman,1in an analysis of 704 cases falling in this group, computed the incidence of recovery to vary between 4 and 6 per cent. This was felt to represent a significant percentage increase. Since the advent of penicillin therapy, in the third period, a considerable number of authors have discussed the principles of treatment, the dosages used and the results obtained with penicillin. The percentage of cured patients has increased until it now is estimated to lie between 60 and 80 per cent. Some of the

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