A Comparison of Serum Aminopeptidase and Alkaline Phosphatase in the Detection of Hepatobiliary Disease in Anicteric Patients

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Abstract
Serum leucine aminopeptidase (LAP) and alkaline phosphatase were assayed concomitantly in 1332 anicteric patients. In patients with benign or malignant bone disease or malabsorption syndrome the serum LAP is usually normal while the alkaline phosphatase level is frequently elevated. In other diseases not involving the hepatobiliary tract or pancreas both enzymes were only occasionally elevated. The LAP test is a more sensitive and a more specific index of hepatobiliary involvement than the alkaline phosphatase. The serum LAP test was a more reliable indicator than the serum alkaline phosphatase for choledocholithiasis, and for liver metastases in the anicteric patient.