Protein tyrosine phosphorylation in cardiovascular system
- 1 August 1995
- journal article
- review article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 149-150 (1) , 87-94
- https://doi.org/10.1007/bf01076567
Abstract
Protein tyrosine phosphorylation is believed to play a central role in signaling pathways initiated by growth factor receptor activation. Recent studies have shown that various vasoactive peptides, in addition to eliciting a contractile response, also serve as growth factors for vascular smooth muscle and stimulate tyrosyl phosphorylation of several endogenous proteins. Some of these proteins have been identified and are similar to those stimulated by growth factor receptor activation. Furthermore, evidence is also accumulating to support an involvement of protein tyrosine phosphorylation, in acute action of groth factors and vasoactive peptides on smooth muscle contractility. This review will briefly summarize the recent work on vasoactive peptide-mediated protein tyrosine phosphorylation in cardiovascular tissues and its potential functional significance.Keywords
This publication has 99 references indexed in Scilit:
- Tyrosine kinase pathways and the regulation of smooth muscle contractilityTrends in Pharmacological Sciences, 1994
- The acute actions of growth factors in smooth muscle systemsLife Sciences, 1994
- Angiotensin II Mediates Intracellular Signaling in Vascular Smooth Muscle Cells by Activation of Tyrosine-Specific Protein Kinases and c-raf-1Biochemical and Biophysical Research Communications, 1993
- Tyrosine Kinase Inhibitors Suppress Agonist-Induced Contraction in Smooth MuscleBiochemical and Biophysical Research Communications, 1993
- The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclaseBiochemical and Biophysical Research Communications, 1992
- Tyrosine kinase inhibitors and the contractile action of epidermal growth factor – urogastrone and other agonists in gastric smooth muscleCanadian Journal of Physiology and Pharmacology, 1992
- Vasopressin dependent tyrosine phosphorylation of a 38 kDa protein in human plateletsBiochemical and Biophysical Research Communications, 1990
- Stimulation of phospholipase C-mediated hydrolysis of phosphoinositides by endothelin in cultured rabbit aortic smooth muscle cellsBiochemical and Biophysical Research Communications, 1989
- Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cellsBiochemical and Biophysical Research Communications, 1988
- Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadateBiochemical and Biophysical Research Communications, 1982