Effects of non-steroidal antiphlogistics on mouse ear oedema induced with dithranol.

  • 1 January 1990
    • journal article
    • Vol. 75  (4) , 287-91
Abstract
Mouse ear oedema induced with dithranol in mice of the CFLP strain was decreased significantly, in a dose-dependent manner, by the oral administration of the following non-steroids 60 minutes before induction of the oedema: piroxicam, proquazone, azapropazone, nifluminic acid and phenylbutazone. An approximately 50% inhibitory effect could be attained with the following doses: 3.3 mg/kg piroxicam, 5 mg/kg proquazone, 5 mg/kg azapropazone, and 1 mg/kg nifluminic acid. Administration of the largest dose (30 mg/kg) of phenylbutazone, used for comparison, resulted in an oedema decrease of 41%.

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