Influenza and the challenge for immunology
Top Cited Papers
Open Access
- 18 April 2006
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 7 (5) , 449-455
- https://doi.org/10.1038/ni1343
Abstract
The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality rate of humans infected with H5N1 are a source of great international concern. A mutant H5N1 virus with the capability to spread rapidly between humans could cause a global catastrophe. Governments have reacted by developing national response plans, stockpiling antiviral drugs and speeding up the development and approval of vaccines. Here we summarize what is known about the interaction between influenza A viruses and the mammalian host response, specifically emphasizing issues that might be of interest to the broader immunology community.Keywords
This publication has 99 references indexed in Scilit:
- The Genesis of a Pandemic Influenza VirusCell, 2005
- Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 VirusesPLoS Biology, 2005
- UNDERSTANDING PRESENTATION OF VIRAL ANTIGENS TO CD8+T CELLS IN VIVO: The Key to Rational Vaccine DesignAnnual Review of Immunology, 2005
- Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populationsNature Immunology, 2005
- A Mutation in the HLA-B*2705-Restricted NP383-391Epitope Affects the Human Influenza A Virus-Specific Cytotoxic T-Lymphocyte Response In VitroJournal of Virology, 2004
- A “universal” human influenza A vaccineVirus Research, 2004
- An Early CD4+ T Cell–dependent Immunoglobulin A Response to Influenza Infection in the Absence of Key Cognate T–B InteractionsThe Journal of Experimental Medicine, 2003
- Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza AProceedings of the National Academy of Sciences, 2003
- Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus InfectionsThe Journal of Experimental Medicine, 2003
- Design and synthesis of carbohydrate-based inhibitors of protein—carbohydrate interactionsCurrent Opinion in Structural Biology, 1996