Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles

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Abstract
The transformation of phencylclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and 6 metabolite were quantitated and the amino acid resulting from the .alpha.-oxidation of the piperidine ring was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, phencyclidine was not converted to [1-(1-phenylcyclohexyl)-2-piperidone].