Receptors as Kissing Cousins
- 7 April 2000
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 288 (5463) , 65-67
- https://doi.org/10.1126/science.288.5463.65
Abstract
It has always been assumed that the numerous members of the huge GPCR family of receptors function in isolation. However, as Graeme Milligan discusses in a Perspective, a host of new findings ( Rocheville et al.) now suggest that related but different GPCRs can bind to each other, and when they do their properties are altered.This publication has 12 references indexed in Scilit:
- A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiaeNature, 2000
- Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptorsNature, 2000
- GABAB receptors – the first 7TM heterodimersTrends in Pharmacological Sciences, 1999
- A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptorNature, 1999
- Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate ReceptorsPublished by Elsevier ,1999
- Identification and Molecular Characterization of m3 Muscarinic Receptor DimersPublished by Elsevier ,1999
- Interaction of the α1B-Adrenergic Receptor with gC1q-R, a Multifunctional ProteinPublished by Elsevier ,1999
- G-protein-coupled receptor heterodimerization modulates receptor functionNature, 1999
- Structural and functional aspects of G protein-coupled receptor oligomerizationBiochemistry and Cell Biology, 1998
- Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and CouplingJournal of Biological Chemistry, 1996