Production of Polycythemia in Rabbits by Anoxia and Cobalt.

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Abstract
Polycythemia was produced in rabbits by anoxia and Co injns. Anoxia is rapidly induced by exposure to simulated altitudes of 20,000 ft., 16 hrs. a day, 5 days a wk. There was apparently no additive effect of the 2 methods. Co slowly induces a polycythemia but is accompanied by symptoms of toxic effects. A study of plasma and whole blood volumes indicate that there may be 2 phases in the development of exptl. polycythemia. First a normal whole blood vol. with a subnormal plasma vol., followed by an increase in plasma vol. and an additional increase in whole blood vol.

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