A study in the maintenance phase of ischaemic acute renal failure in the rat
- 1 March 1990
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 138 (3) , 349-357
- https://doi.org/10.1111/j.1748-1716.1990.tb08857.x
Abstract
The fate of the trapped deformed erythrocytes seen in the early recirculation phase after ischaemia and the generation of long Tamm-Horsfall (TH) cylinders in the renal medulla during the first week after recirculation was studied in rats. In an in-vitro study the effects of different concentrations of TH protein on the permeability to Na+ of a semipermeable membrane were also investigated. The trapping of erythrocytes was found to be a reflow phenomenon, as there was no increase in the capillary area of the medulla in kidneys subjected to ischaemia but with no recirculation. This area increased to a maximum of 34.6 .+-. 2.07% 20 min after recirculation and decreased to a normal value of 3.3 .+-. 0.74% 1 day after the primary ischaemia. The area occupied by cylinders increased to a maximum of 19.2 .+-. 1.4% 2 days after the primary damage and was as large as 16.7 .+-. 1.47% after 1 week. It was also shown that the diffusion half-time of Na+ ions across a semipermeable membrane increased from 11.4 .+-. 0.45 min to a maximum of 32.2 .+-. 2.19 min with a protein concentration of 1 mg ml-1. It was concluded that the trapping of erythrocytes alone could not explain the decrease in renal function 1 week after the primary damage, but that the blockade of the tubules by the long homogeneous TH cylinders could be responsible for this decrease.Keywords
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