Molecular Epidemiology of Preeclampsia
- 1 January 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Obstetrical & Gynecological Survey
- Vol. 58 (1) , 39-66
- https://doi.org/10.1097/00006254-200301000-00022
Abstract
Numerous articles have been published that address the possible genetic influences on the development of preeclampsia (PE). However, to our knowledge, a complete review of the results has not yet been completed. We undertook a MEDLINE search to identify English-language articles published after January 1, 1990 that examined the possible role of specific genes in the etiology of PE. After a brief introduction and a concise review of the prevailing etiologic hypotheses, we have categorized the candidate genes into six categories, based on their hypothesized role in PE etiology. The purpose of this paper is to review the literature, comment on its quality, and provide a reference for researchers interested in the molecular epidemiology of preeclampsia. Obstetricians & Gynecologists, Family Physicians. After completion of this article, the reader will be able to list the prevailing etiologic hypotheses of preeclampsia, to outline the published data on possible genetic influence on the development of preeclampsia, and to clearly state the definition of preeclampsia.Keywords
This publication has 160 references indexed in Scilit:
- The Factor V Leiden Mutation Is Not a Common Cause of Pregnancy-Induced Hypertension in JapanSeminars in Thrombosis and Hemostasis, 1999
- Detection of factor V Leiden mutation in severe pre‐eclamptic Hungarian womenClinical Genetics, 1998
- Pregnancy Induces an Increase in Angiotensin II Type-1 Receptor Expression in Uterine But Not Systemic Artery EndotheliumEndocrinology, 1997
- The factor V Leiden mutation may predispose women to severe preeclampsiaAmerican Journal of Obstetrics and Gynecology, 1996
- Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A new method to identify the G1528C mutation in genomic DNA showing its high frequency (≈90%) and identification of a new mutation (T2198C)Journal of Inherited Metabolic Disease, 1996
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseNature Genetics, 1995
- Mutation in blood coagulation factor V associated with resistance to activated protein CNature, 1994
- Renin gene restriction fragment length polymorphisms do not show linkage with preeclampsia and eclampsiaPublished by Wiley ,1994
- Is genetic susceptibility to pre‐eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus?BJOG: An International Journal of Obstetrics and Gynaecology, 1991
- An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.Journal of Clinical Investigation, 1990