Laser desorption electron impact: application to a study of the mechanism of conjugation of glutathione and cyclophosphamide

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Abstract
Toward the objective of producing ion radical species from involatile anfd thermally labile samples, we have combimed laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.