INCREASES IN SERUM CONCENTRATIONS OF FOLLICLE-STIMULATING HORMONE (FSH) DURING THYROTROPHIN-RELEASING HORMONE (TRH) INFUSIONS IN NORMAL MEN

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Abstract
Increases in serum FSH values to approximately 50% above basal concentrations were found during TRH infusions of 2.0 .mu.g/min into normal men. These increases could not be explained by cross-reactivity of thyrotropin (TSH) in the FSH assay. No significant change was found in serum concentrations of FSH during saline infusions nor in LH [luteinizing hormone] concentrations during either TRH or saline infusions. Many previous studies using single injections of TRH have failed to demonstrate changes in serum FSH concentrations. Prolonged infusions of TRH, as used in this study may be more likely to lead to non-specificity of the effects of this tripeptide on pituitary hormone secretion.