Reductive DNA Cleavage Induced by UVA Photoirradiation of NADH without Oxygen
- 1 September 2006
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (38) , 12372-12373
- https://doi.org/10.1021/ja065073i
Abstract
UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.Keywords
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