Short report: the effect of ranitidine on the post‐prandial absorption of a low dose of alcohol

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Abstract
SUMMARY: Twenty healthy male subjects were studied twice using a double‐blind, randomized placebo controlled, cross‐over study design. Alcohol absorption (integrated 2‐h plasma alcohol concentration, peak plasma alcohol concentration, and time to reach peak concentration) was measured after 8 daily doses of either placebo or 300 mg ranitidine. They were given alcohol, 0.15 g/kg of body weight by month after an evening meal. Compared with placebo, there was a trend towards higher integrated 2‐h plasma alcohol concentrations (3.17 and 3.89 mg. h/dL, respectively, P= 0.07), and a statistically significant increase in mean peak plasma alcohol concentration after dosing with ranitidine (4.92 and 6.47 mg/dL, respectively, P= 0.05).