Vitamin D resistant hypophosphatemic osteomalacia associated with osteosarcoma of the mandible: Report of a case.

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Abstract
A case of vitamin D resistant hypophosphatemic osteomalacia associated with osteosarcoma of the mandible is presented. The patient complained of lumbar, knee and foot pain and muscle weakness of 2 yr duration. Serum phosphorus was 1.0-1.6 mg/dl, tubular reabsorption of phosphorus was 47-58%, TmPO4/GFR was 0.7-1.2 mg/dl. Aminoaciduria was noted. Bone biopsy confirmed the diagnosis of osteomalacia. He partially responded to the treatment with 1.alpha.(OH)D3 and sodium phosphate. After removal of sarcoma of the mandible, symptoms remitted and pertinent laboratory data became normal except serum alkaline phosphatase for more than 1 yr without treatment. An impaired response of the tubule and bone to active vitamin D3, caused in some way by the osteosarcoma, might be one of the causes of osteomalacia in this case.

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