Human Lactational and Ovarian Response to Endogenous Prolactin Release
- 8 September 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4052) , 897-900
- https://doi.org/10.1126/science.177.4052.897
Abstract
Radioimmunoassayable prolactin rises in postpartum women during nursing and after intravenous thyrotropin-releasing hormone (TRH). Prolactin release induced by TRH can be dissociated from the postsuckling response. In addition to this, increases in endogenous prolactin secretion are followed by marked breast engorgement and milk letdown, especially after intravenous TRH. In this group of breast-feeding women, vaginal smears remained atrophic even up to 410 postpartum days. Prolactin appears to influence the production of breast milk, and the maintenance of a regular nursing pattern seems to promote the maintenance of ovarian unresponsiveness to circulating gonadotropins.Keywords
This publication has 6 references indexed in Scilit:
- Studies of prolactin secretion in human pregnancyAmerican Journal of Obstetrics and Gynecology, 1972
- Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamideBiochemical and Biophysical Research Communications, 1971
- Human prolactin: Isolation and some propertiesBiochemical and Biophysical Research Communications, 1971
- Thyrotropin releasing hormone: Direct evidence for stimulation of prolactin production by pituitary cells in cultureBiochemical and Biophysical Research Communications, 1971
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962
- Endocrine studies of lactation amenorrheaAmerican Journal of Obstetrics and Gynecology, 1961