The Nature of the Neuromuscular Block Produced by Neomycine

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Abstract
Elmqjvist, D. and J.‐O. Josefsson. The nature of the neuromuscular block produced by neomycine. Acta physiol. scand. 1962. 54. 105–110. – The neuromuscular block produced by neomycine has been studied in the rat diaphragm and the frog sartorius by means of intra‐ and extracellular recording techniques. The block is due to a reduction in the amplitude of the end‐plate potential. This reduction is partly caused by a neomycine induced decrease in the sensitivity of the postjunctional end‐plate membrane to the depolarizing action of acetylcholine. Neomycine reduces the amount of transmitter released from the motor nerve in response to a nerve volley or to a high external potassium concentration. This prejunctional effect of neomycine is antagonized by an excess of Ca ions.