Relation between Relative Cerebral Blood Flow, Relative Cerebral Blood Volume, and Mean Transit Time in Patients with Acute Ischemic Stroke Determined by Perfusion-Weighted MRI

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Abstract
The relation between relative cerebral blood flow (relCBF), relative cerebral blood volume (relCBV), and mean transit time (MTT) changes was examined in 20 patients with acute cerebral ischemia (0.549) resulted in a better fit than using a linear function for the correlation of relCBF and relCBV. MTT ratios increased steadily with decreasing CBF values. In conclusion, there is a clear relation between different perfusion-weighted magnetic resonance imaging parameters in acute ischemia, reflecting both the degree of hemodynamic failure as well as compensatory mechanisms including vasodilation.