TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells
Open Access
- 23 January 2009
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 58 (4) , 894-905
- https://doi.org/10.2337/db08-1187
Abstract
OBJECTIVE Polymorphisms in the human TCF7L2 gene are associated with reduced insulin secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level on mature β-cell function and suggest a potential mechanism for its actions.Keywords
This publication has 46 references indexed in Scilit:
- A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancerProceedings of the National Academy of Sciences, 2008
- Transcription Factor 7–like 2Polymorphism and Colon CancerCancer Epidemiology, Biomarkers & Prevention, 2008
- Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetesJournal of Clinical Investigation, 2007
- TCF7L2 Polymorphisms Modulate Proinsulin Levels and β-Cell Function in a British Europid PopulationDiabetes, 2007
- A genome-wide association study identifies novel risk loci for type 2 diabetesNature, 2007
- TCF7L2: the biggest story in diabetes genetics since HLA?Diabetologia, 2006
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 2006
- WNT and β-catenin signalling: diseases and therapiesNature Reviews Genetics, 2004
- Down-Regulated Expression of Exocytotic Proteins in Pancreatic Islets of Diabetic GK RatsBiochemical and Biophysical Research Communications, 2002
- Global and societal implications of the diabetes epidemicNature, 2001