Gastrin

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Abstract
(Second of Two Parts)Gastrin in Human DiseaseHypergastrinemia without Gastric Hypersecretion Pernicious anemia; atrophic gastritis. Serum gastrin concentrations are increased in patients with atrophic gastritis. The increase is especially marked in gastritis that spares the antrum and is associated with circulating parietal-cell antibodies. In some patients with this type of gastritis pernicious anemia develops as a result of loss of intrinsic-factor secretion.126 Approximately three fourths of the patients with pernicious anemia were found to have increased fasting serum gastrin concentrations, and about one third were in the hypergastrinemic range characteristic of Zollinger-Ellison syndrome.127 Chronic hypochlorhydria apparently leads to . . .