The biosynthesis of sclerin
- 1 January 1971
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 2703-2708
- https://doi.org/10.1039/j39710002703
Abstract
The biosynthesis of sclerin, a physiologically active metabolite produced by a Sclerotinia fungus, has been investigated by feeding experiments with [1-14C]- and [2-14C]-acetate, and [14C]formate. As a result, a biosynthetic scheme involving two separate polyacetyl chains is proposed. This mechanism is extended to explain the biosyntheses of the co-metabolites and the possibility of its operating in polyketide biosynthesis more widely than is conceived at present is suggested. It has been shown that the lead tetra-acetate method of decarboxylation can be a useful alternative of Schmidt degradation in tracer studies.Keywords
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