INVITRO AND INVIVO ACTIVITY OF STREPTOMYCIN AND ISONIAZID SINGLY AND IN COMBINATION
- 1 January 1953
- journal article
- research article
- Published by Elsevier
- Vol. 67 (6) , 808-827
- https://doi.org/10.1164/art.1953.67.6.808
Abstract
Streptomycin exerts greater tuberculocidal effect than isoniazid: There was also a slower emergence of resistance to combinations of streptomycin and isoniazid than to either compound alone. Neither compound prevents the ultimate emergence of resistance to the other. Cross-resistance occurs under certain conditions although isoniazid is effective against streptomycin-resistant organisms not previously exposed to isoniazid, and streptomycin is effective against isoniazid-resistant organisms not previously in contact with streptomycin. Under ideal conditions, streptomycin and isoniazid may act synergistically.Keywords
This publication has 1 reference indexed in Scilit:
- THE ENUMERATION OF VIABLE TUBERCLE BACILLI IN CULTURES AND INFECTED TISSUESAnnals of the New York Academy of Sciences, 1949