Conceptually New Sulfone Analogues of the Hormone 1α,25-Dihydroxyvitamin D3: Synthesis and Preliminary Biological Evaluation
- 14 August 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 42 (18) , 3425-3435
- https://doi.org/10.1021/jm990267c
Abstract
A conceptually new series of vitamin D3-like nonfluorinated and fluorinated 16-ene side chain tert-butyl sulfones 3−7 has been synthesized. Even though these novel C,D-ring side chain analogues of the hormone 1α,25-dihydroxyvitamin D3 (1, 1,25D3) lack a terminal OH group, thought previously to be essential for high biological activity, they are highly antiproliferative and, in several cases, transcriptionally active in vitro but desirably noncalcemic in vivo. The side chain sulfone group may be binding to the nVDR as a hydrogen-bond acceptor, in contrast to the hydrogen-bond donor function of the 25-OH group of natural 1,25D3.Keywords
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