Nucleation of One Polymorph by Another
- 1 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (21) , 6380-6381
- https://doi.org/10.1021/ja0351544
Abstract
Nucleation of one polymorph by another has been observed directly in the melt crystallization of d-mannitol and d-sorbitol. The new polymorph nucleated on an existing one and grew to dominate the end product. This effect is relevant to controlling polymorphism in the manufacture of specialty chemicals and to developing theories of polymorphic nucleation and concomitant polymorphs, for which current efforts emphasize homogeneous nucleation of alternative polymorphs.Keywords
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