NATURAL ANTIBODY-RESPONSE TO ESCHERICHIA-COLI INCLUDES ANTIBODIES OF IGD CLASS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 31  (1) , 104-110
Abstract
Antibodies to E. coli of the Ig[immunoglobulin]M, IgG and IgA class are readily demonstrable in normal human serum. Using the sensitive red cell-linked antigen-antiglobulin system, it was demonstrated that antibodies of the IgD class are also part of this normal response. The IgD antibody titer was low and often could only be demonstrated in partially purified IgD preparations. The availability of purified IgD paraproteins and their Fab.delta. and Fc.delta. fragments, as well as antisera specific for these fragments, allowed the necessary critical specificity controls to be performed.