Endogenous natriuretic factors: atrial natriuretic hormone and digitalis-like substance in Cushing's syndrome
- 1 June 1991
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 129 (3) , 453-458
- https://doi.org/10.1677/joe.0.1290453
Abstract
In order to investigate the effect of chronic hypercortisolaemia on endogenous natriuretic factors (atrial natriuretic hormone (ANH) and the Na+/K+ pump inhibitor) digitalis-like substance (DLS), and their relation to hypertension, 28 patients with pituitary-or adrenal-dependent Cushing's syndrome and six patients on high-dose prednisone treatment were studied. Plasma ANH levels were increased in patients with Cushing's syndrome (36·0±1·4 (s.e.m.) ng/l) compared with those in healthy controls (28·6±1·3 ng/l, P P P 3H]ouabain to erythrocytes was not altered in patients with hypercortisolaemia. Slightly decreased DLS activity in the erythrocyte 86Rb uptake inhibition assay was found in patients with Cushing's syndrome (52·9±2·7%) compared with that in controls (60·9±1·8%, P r = 0·52, PJournal of Endocrinology (1991) 129, 453–458Keywords
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