Disseminated Melanoma — Is There a New Standard Therapy?

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Abstract
Melanoma presents formidable problems at both ends of the clinical spectrum — from prevention and early detection to treatment of metastatic disease. In white populations, the worldwide incidence of invasive primary cutaneous melanoma has been rising for decades, making it a public health issue of growing importance. In the United States, the rate of increase in the incidence of melanoma, about 4 percent per year, is greater than that of any other cancer; 32,000 new cases of melanoma are expected in 1992.In the management of primary disease, however, there is some good news: the case fatality rate has decreased . . .