Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4+-T-Cell Subsets Are Determined Only by Coreceptor Expression
Open Access
- 1 November 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (21) , 10455-10459
- https://doi.org/10.1128/jvi.75.21.10455-10459.2001
Abstract
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4+T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.Keywords
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