Das Verhalten der Oxalsäure bei der Leberdurchströmung1 in vitro (VI. Mitteilung)

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Abstract
The livers for the perfusion expts. were obtained from rabbits which had been fasted for 24 hrs. The livers were perfused with a mixture of 1 part rabbit blood and 4 parts Tyrode soln. Fasting blood of rabbits contains 0.3-0.4 mg. % oxalic acid, so the perfusion soln. was considered to contain 0.07 mg. % oxalic acid. The glucose conc. in the perfusion soln. was usually adjusted to 0.1% and the various substances studied then added. Oxalic acid in the soln. was detd. at the beginning of the expt., and 1/2, 1, 2, and 4 hrs. thereafter. Rabbit liver was not able to destroy oxalic acid. The liver was able to form oxalic acid from glucose, citric acid, butyric acid, creatinine, glycolic acid, succinic acid, and glycine. Large amts. of oxalic acid seemed to disturb the carbohydrate metabolism and cause the formation of still more oxalic acid. Glycine seemed to be able to form and to detoxify oxalic acid.

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