The many faces of filamin: A versatile molecular scaffold for cell motility and signalling
Top Cited Papers
- 1 November 2004
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 6 (11) , 1034-1038
- https://doi.org/10.1038/ncb1104-1034
Abstract
Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.Keywords
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