Utilization of Adenosine Triphosphate in Rat Mast Cells during and after Secretion of Histamine in Response to Compound 48/80

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Abstract
The ATP content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 s exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/103 cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/103 cells per min, which may be associated with recovery of the cells.

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