Correlation between anti-inflammatory activity and peripheral drug in rat after administration of biphenylylacetic acid derivatives.

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Abstract
The relationship between the antiinflammatory action and drug behaviors in vivo was investigated by administering 5 biphenylylacetic acid derivatives to rats. With 5 drugs, an excellent linear relationship was recognized between % inhibition of carrageenin-induced edema and logarithm of drug concentration in peripheral compartment calculated pharmacokinetically (r [correlation coefficient] = 0.76-0.96). A good linear relationship between areas under % inhibition vs. time curves, and logarithm of drug concentration in peripheral compartment vs. time curves of each drug was also recognized (r = 0.86). These results suggested that intrinsic drug activities of each drug are approximately the same and drug effect may be restricted to their transporting abilities into peripheral compartment.