EFFECT OF COBALT IONS ON MYOCARDIAL METABOLISM
- 1 August 1967
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 45 (8) , 1219-1223
- https://doi.org/10.1139/o67-142
Abstract
Cobalt treatment (4 mg/kg intraperitoneally for 8 days) significantly depressed the oxygen uptake of rat heart mitochondria incubated in pyruvate, octanoate, and stearate media. Cobalt treatment did not, however, affect oxygen uptake in cardiac mitochondria prepared from thiamine-deficient rats. The addition of α-lipoic acid to the in vitro system greatly enhanced the ability of mitochondria from cobalt-treated rats to metabolize pyruvate. Cobalt treatment in vivo did not appear to exert any inhibitory effect on myocardial succinic dehydrogenase activity.This publication has 7 references indexed in Scilit:
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