Plasma Renin Activity Following Central Infusion of Angiotensin II and Altered CSF Sodium Concentration in the Conscious Goat

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Abstract
To study central influences on the renal release of renin, angiotensin II was infused into the lateral cerebral ventricle of conscious hydrated goats. CSF Na concentration was increased or lowered by similar infusions of hypertonic NaCl or of isotonic fructose solution. Infusion of angiotensin II in doses from 0.5-1 .mu.g decreased plasma renin activity (PRA) and increased blood pressure, antidiuresis, natriuresis and thirst. Intraventricular infusion of hypertonic NaCl also suppressed PRA, induced antidiuresis, natriuresis and an inconsistent rise in blood pressure. Lowering of CSF [Na+] by infusion of isotonic fructose increased PRA and was followed by a water diuresis in the non-hydrated animal. The fructose infusions caused some decrease in renal K+ excretion but no consistent change in renal Na+ excretion. Angiotensin II and changes in Na balance probably modulate renal renin release also via the CNS.