Optical Transduction Of Chemoreceptive Events: Towards A Fiber-Optic Biosensor

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Abstract
Phosphatidyl choline-cholesterol and stearic acid monolayers and multilayers were deposited onto borosilicate glass, quartz and crystalline silicon surfaces by transfer from the air-water interface of a Langmuir-Blodgett trough. Contact angle, ellipsometric, X-ray photoelectron and fluorescence measurements provided characterization of phospholipid monolayers on hydrated or alkylated silicate surfaces. A fluorescent lipid film supported on a quartz optical fiber demonstrated the feasibility of preparation of an evanescent-wave based intrinsic optrode. Further development of intrinsic biosensors based on lipid membrane structures is described in terms of optical conduction of lipid multilayer wave guides, and new membrane-soluble fluorescence probes such as trans-4-dimethylamino-4'-(1-oxobutyl)stilbene.

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