Nicotinic Acid Oxidation in Pseudomonas fluorescens.

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Abstract
The destruction of nicotinic acid by Pseudomonas fluorescens, previously described by Koser and Baird3 was found to be an enzymic oxidation. Utilization of nicotinic acid is accompanied by oxygen uptake at a ratio of about 3 oxygen to 1 nicotinic acid. Nicotinamide is not attacked by the oxidase under our experimental conditions. Two types of inhibitors interfere with the enzymatic destruction of nicotinic acid: inhibitors of heavy metal enzymes, such as sodium azide and hydroxylamine, and surface active agents, such as octyl alcohol, toluene and lauryl pyridinium chloride. The rate of oxygen consumption indicates a destruction of the nicotinic acid molecule. Since nicotinic acid serves as a substrate and not as a co-enzyme it should be noted that this reaction sets it apart from its known function in the co-factors.

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