TUMOR-PRODUCING EFFECT OF AUTOMOBILE EXHAUST CONDENSATE AND FRACTIONS THEREOF .1. CHEMICAL STUDIES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 1  (5) , 661-667
Abstract
The criteria of a biological detection system discriminating carcinogenic and non-carcinogenic fractions of a mixture are discussed. Automobile exhaust gas condensate (in total 545.5 g) produced by a passenger car during the Europa driving cycle was separated into fractions with and without polycyclic aromatic hydrocarbons (PAH) by liquid-liquid distribution between methanol + water + cyclohexane and cyclohexane + nitromethane, respectively. PAH are highly potent carcinogens. To test non-PAH contribution to the total carcinogenic effect, these were separated from the PAH-containing fraction. Carbazol and acridine derivatives as well as aromatic amines remain predominantly in the PAH-free methanolic phase.