Effects of Pentobarbital on Contractile Responses of Feline Cerebral Arteries

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Abstract
The effects of pentobarbital on the contractile responses of isolated feline middle cerebral arteries have been examined. In the presence of pentobarbital (3 × 10−4 M), the maximum contractions effected by potassium, noradrenaline, and prostaglandin F2α were reduced by 37 ± 3, 69 ± 3, and 10 ± 6%, respectively. The results caution against the use of pentobarbital as an anaesthetic agent in investigations of cerebrovascular reactivity.