Specimen Weight and M.S. 222

Abstract
The influence of specimen weight upon induction of and recovery from Stage I M.S. 222 (ethyl m-aminobenzoate methanesulphonate) was examined in goldfish (Carassius auratus), brook (Salvelinus fontinalis), and rainbow trout (Salmo gairdneri) exposed to various anesthetic concentration–temperature combinations. Both induction and recovery times varied inversely with weight, the influence of weight being particularly pronounced among smaller specimens. These observations are consistent with the hypothesis that attainment of "critical" internal anesthetic concentration is influenced by weight-specific variation in the relationship between gill area and extracellular phase volume.

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