Purine analogues as amplifiers of phleomycin. III. Some 2-alkylthio derivatives of imidazole, benzimidazole, benzoxazole and benzothiazole
- 1 January 1978
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 31 (2) , 447-450
- https://doi.org/10.1071/ch9780447
Abstract
Some 2-methylthio and 2-carbamoylalkylthio derivatives of 1-methylimidazole, benzimidazole, benzoxazole, benzothiazole and 6-dimethylaminobenzothiazole have been synthesized by alkylation of the corresponding thiones. Their in vitro activities, as amplifiers of phleomycin against Escherichia coli, varied from slight to high but none was outstanding. 2-(Benzothiazol-2'-ylthio)acetamide (2j)showed maximal activity at c. 0.04 mM with progressive decreases at both higher and lower concentrations.Keywords
This publication has 2 references indexed in Scilit:
- Thiazolo[5,4-d]pyrimidine derivatives as amplifiers of phleomycin against Escherichia coliAustralian Journal of Chemistry, 1977
- Purine studies. XIX. Rodential metabolism of 2-(6',8',9'-Trimethylpurin-2'-ylthio)propionamide and related purinesAustralian Journal of Chemistry, 1976