Calcification of Aging Articular Cartilage in Man
Open Access
- 1 January 1979
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 50 (6) , 613-619
- https://doi.org/10.3109/17453677908991282
Abstract
Calcification of the articular cartilage was studied ultrastructurally using normal femoral heads obtained from necropsies of persons ranging in age from 11 months to 80 years. Mineral crystals which appeared during the initial stages of deposition were morphologically divided into two types. Type A crystals were slender, twisted and curved, measuring from 100 nm to 360 nm in length. Type B crystals were short, needle-like and slightly curved, measuring from 30 nm to 160 nm in length. Type A crystals were found mainly in the developing epiphysis during childhood. Type B crystals were generally found in the calcified zone of adult articular cartilage. Both types of crystals initially appeared in close proximity to extracellular membrane-invested electron dense particles called “matrix vesicles”, and gradually increased in number to form calcified cartilage matrix. The morphological differences between type A and B crystals might be caused by biochemical alterations of the cartilage matrices and/or biomechanical changes in the joints of children and adults.Keywords
This publication has 17 references indexed in Scilit:
- The distributions of chondroitin sulfates in articular and growth cartilages of human bonesBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- The Ultrastructure and Biomechanical Significance of the Tidemark of Articular CartilageClinical Orthopaedics and Related Research, 1975
- Mitochondrial Calcium and Its Role in CalcificationPublished by Wolters Kluwer Health ,1974
- Ultrastructural observations of initial calcification in dentine and enamelJournal of Ultrastructure Research, 1972
- Role of mitochondria in calcification. Mitochondrial activity distribution in the epiphyseal plate and accumulation of calcium and phosphate ions by chondrocyte mitochondriaBiochemical and Biophysical Research Communications, 1972
- The Locus of Initial Calcification in Cartilage and BoneClinical Orthopaedics and Related Research, 1971
- The relationship of cartilage canals to the initial osteogenesis of secondary centers of ossificationThe Anatomical Record, 1970
- VESICLES ASSOCIATED WITH CALCIFICATION IN THE MATRIX OF EPIPHYSEAL CARTILAGEThe Journal of cell biology, 1969
- Histochemical Studies of Rheumatic ConditionsAnnals of the Rheumatic Diseases, 1953
- Calcification and ossification calcification of developing bones in embryonic and newborn ratsThe Anatomical Record, 1940