The effects of preanesthetic, anesthetic, and postoperative drugs on renal function

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Abstract
Morphine produces a decrease in urine flow in certain animals and man. There is evidence in animals that this antidiuresis may be attributed to a release of antidiuretic hormone (ADH). In man, morphine may result in decreased urine flow that is attributable to decreased renal hemodynamics in the absence of increased ADH. Although the evidence is less clear, the situation is apparently similar for meperidine and barbiturates.General anesthetic agents result in decreased renal blood flow, filtration rate, and excretion of water and electrolytes. It is possible that these renal effects are the result of some as yet undetermined consequences of the anesthetic state rather than of a specific drug action.

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