Error filtration, interference, and the human linkage map.
- 1 August 1991
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (15) , 6501-6505
- https://doi.org/10.1073/pnas.88.15.6501
Abstract
Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.Keywords
This publication has 15 references indexed in Scilit:
- The CEPH consortium linkage map of human chromosome 1Genomics, 1991
- Guidelines for human linkage maps: An international system for human linkage maps (ISLM, 1990)Genomics, 1991
- Guidelines for human linkage maps An International System for Human Linkage Maps (ISLM, 1990)Annals of Human Genetics, 1991
- Standard maps of chromosome 10Annals of Human Genetics, 1990
- A Common Language for Physical Mapping of the Human GenomeScience, 1989
- MAP, an expert system for multiple pairwise linkage analysisAnnals of Human Genetics, 1989
- Construction of multilocus genetic linkage maps in humans.Proceedings of the National Academy of Sciences, 1987
- Tests of hypotheses on recombination frequenciesGenetics Research, 1985
- A Mapping Function for ManHuman Heredity, 1977
- SEQUENTIAL TESTS FOR THE DETECTION OF LINKAGE1955