Metabolism of N -2-Fluorenylacetamide in X/Gf Mice: Lack of Correlation Between Biochemical Interaction and Carcinogenicity
- 1 March 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (3) , 649-651
- https://doi.org/10.1093/jnci/56.3.649
Abstract
A comparative study of the metabolism of the carcinogen N-2-fluorenylacetamide by mice of the X/Gf strain (resistant to the tumorigenic action) and the NIH Swiss strain (susceptible to the tumorigenic action) showed slight but not outstanding differences in metabolic patterns. The activated metabolite N-hydroxy-N-2-fluorenylacetamide was excreted by both strains, and the levels of carcinogens or metabolites bound to liver macromolecular constituents were comparable in the X/Gf and NIH Swiss mice.Keywords
This publication has 5 references indexed in Scilit:
- Separation of the urinary metabolites of N-2-fluorenylacetamide on columns of DEAE-cellulose anion exchangerBiochemical Pharmacology, 1967
- Enzymatic N-Hydroxylation of the Carcinogen 2-Acetylaminofluorene and the Metabolism of N-Hydroxy-2-acetylaminofluorene-9-14C in VitroJournal of Biological Chemistry, 1964
- COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE + ITS N-HYDROXY METABOLITE IN MICE HAMSTERS + GUINEA PIGS1964
- ON THE MECHANISM OF PROTEIN BINDING OF N-2-FLUORENYLACETAMIDE - THE DEACETYLATION OF N-(1-HYDROXY-2-FLUORENYL)-ACETAMIDE AND THE EFFECT OF ETHIONINE1960
- Biochemical Investigations on Hepatic Carcinogenesis1, 2JNCI Journal of the National Cancer Institute, 1955