Modification and cleavage of DNA by ptaquiloside. A new potent carcinogen isolated from bracken fern

1 January 1989

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 22,p. 1775-1777
https://doi.org/10.1039/c39890001775

Abstract

The dienone (2), the active species chemically derived from bracken carcinogen ptaquiloside (1), has been shown to bind to purine bases of salmon sperm DNA covalently and to cleave double strand supercoiled pBR 322 DNA.

Keywords

PTAQUILOSIDE
NEW POTENT
STRAND SUPERCOILED
SPECIES CHEMICALLY
SUPERCOILED PBR
CLEAVE DOUBLE
CHEMICALLY DERIVED
POTENT CARCINOGEN
ACTIVE SPECIES
BRACKEN FERN